Kuhl, Ellen, Prof. Dr.-Ing.
Prof. Dr.-Ing. Ellen Kuhl
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Automated Model Discovery for Soft Matter Systems
(Third Party Funds Single)
Project leader: ,
Term: 1. July 2024 - 30. June 2029
Acronym: DISCOVER
Funding source: EU / European Research CouncilAutomated models boosting research on soft matter
Soft materials, which can be easily deformed or structurally altered by thermal or mechanical stress, are essential in modern life, affecting autonomy, sustainability and health. However, accurately modelling these materials is complex and usually limited to a few well-trained experts. The ERC-funded DISCOVER project aims to make constitutive modelling more accessible through automated model discovery. Objectives include developing neural networks that autonomously find the best models, parameters and experiments for various soft matter systems. Furthermore, researchers will assess model performance in different experiments and use Bayesian analysis to measure uncertainties. Automated model discovery should enable exploration of a vast range of model parameters, offering insight into soft matter systems that traditional methods cannot achieve.
2026
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A complement to neural networks for anisotropic inelasticity at finite strains
In: Computer Methods in Applied Mechanics and Engineering 450 (2026), Article No.: 118612
ISSN: 0045-7825
DOI: 10.1016/j.cma.2025.118612 - , , :
Material Fingerprinting for rapid discovery of hyperelastic models: First experimental validation
In: Journal of the Mechanics and Physics of Solids 208 (2026), Article No.: 106463
ISSN: 0022-5096
DOI: 10.1016/j.jmps.2025.106463 - , , , , , , , :
Reanimating the past: From historical collections of the placenta and uterus to modern imaging, machine learning, and multiscale modeling
In: Placenta (2026)
ISSN: 0143-4004
DOI: 10.1016/j.placenta.2026.02.013
2025
- , , , :
Material Fingerprinting: A shortcut to material model discovery without solving optimization problems
In: Computer Methods in Applied Mechanics and Engineering 450 (2025)
ISSN: 0045-7825
DOI: 10.1016/j.cma.2025.118573 - , , , :
Convex neural networks learn generalized standard material models
In: Journal of the Mechanics and Physics of Solids 200 (2025), Article No.: 106103
ISSN: 0022-5096
DOI: 10.1016/j.jmps.2025.106103 - , , :
Discovering uncertainty: Bayesian constitutive artificial neural networks
In: Computer Methods in Applied Mechanics and Engineering 433 (2025), Article No.: 117517
ISSN: 0045-7825
DOI: 10.1016/j.cma.2024.117517 - , , :
Generalized invariants meet constitutive neural networks: A novel framework for hyperelastic materials
In: Journal of the Mechanics and Physics of Solids 206 (2025), Article No.: 106352
ISSN: 0022-5096
DOI: 10.1016/j.jmps.2025.106352 - , , , :
Discovering dispersion: How robust is automated model discovery for human myocardial tissue?
In: Biomechanics and Modeling in Mechanobiology (2025)
ISSN: 1617-7959
DOI: 10.1007/s10237-025-02005-x - , , , , :
Robust material model discovery for human myocardium
30th Congress of the European Society of Biomechanics (ESB) (Zürich, Switzerland, 6. July 2025 - 9. July 2025)
2024
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Automated model discovery for human cardiac tissue
conference, Netzwerktagung der Alexander von Humboldt Stiftung (Erlangen, 21. November 2024) - , , , , , :
Automated model discovery for human cardiac tissue: Discovering the best model and parameters
In: Computer Methods in Applied Mechanics and Engineering 428 (2024), Article No.: 117078
ISSN: 0045-7825
DOI: 10.1016/j.cma.2024.117078 - , , , , , :
Constitutive neural networks for model discovery of myocardial tissue
conference, CMBBE 2024 SYMPOSIUM, 19th International Symposium on Computer Methods in Biomechanics and Biomedical Engineering (Vancouver, 30. July 2024 - 1. August 2024) - , , , , , , , , , , , :
The mechanical and sensory signature of plant-based and animal meat
In: npj Science of Food 8 (2024), Article No.: 94
ISSN: 2396-8370
DOI: 10.1038/s41538-024-00330-6
2020
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Modeling the life cycle of the human brain
In: Current Opinion in Biomedical Engineering (2020)
ISSN: 2468-4511
DOI: 10.1016/j.cobme.2019.12.009
URL: https://www.sciencedirect.com/science/article/pii/S2468451119300832?via=ihub - , , , , :
Fifty Shades of Brain: A Review on the Mechanical Testing and Modeling of Brain Tissue
In: Archives of Computational Methods in Engineering 27 (2020), p. 1187–1230
ISSN: 1134-3060
DOI: 10.1007/s11831-019-09352-w
URL: https://link.springer.com/article/10.1007/s11831-019-09352-w - , , , , , , , , , , :
Towards microstructure-informed material models for human brain tissue
In: Acta Biomaterialia 104 (2020), p. 53-65
ISSN: 1742-7061
DOI: 10.1016/j.actbio.2019.12.030
URL: https://www.sciencedirect.com/science/article/pii/S1742706119308682?via=ihub - , , , , , :
Folding drives cortical thickness variations
In: European Physical Journal - Special Topics 229 (2020), p. 2757-2778
ISSN: 1951-6355
DOI: 10.1140/epjst/e2020-000001-6
2019
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Challenges and perspectives in brain tissue testing and modeling
In: Proceedings in Applied Mathematics and Mechanics accepted (2019)
ISSN: 1617-7061
DOI: 10.1002/pamm.201900269
2018
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Region‐ and loading‐specific finite viscoelasticity of human brain tissue
In: Proceedings in Applied Mathematics and Mechanics 18 (2018), Article No.: e201800169
ISSN: 1617-7061
DOI: 10.1002/pamm.201800169 - , , , :
Symmetry Breaking in Wrinkling Patterns: Gyri Are Universally Thicker than Sulci
In: Physical Review Letters 121 (2018), Article No.: 228002
ISSN: 0031-9007
DOI: 10.1103/PhysRevLett.121.228002
2017
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Wrinkling instabilities in soft bi-layered systems
In: Philosophical Transactions of the Royal Society A-Mathematical Physical and Engineering Sciences 375 (2017)
ISSN: 1364-503X
DOI: 10.1098/rsta.2016.0163 - , , , , , , , , , , :
Mechanical characterization of human brain tissue
In: Acta Biomaterialia 48 (2017), p. 319–340
ISSN: 1742-7061
DOI: 10.1016/j.actbio.2016.10.036 - , , , , , :
Rheological characterization of human brain tissue
In: Acta Biomaterialia (2017)
ISSN: 1742-7061
DOI: 10.1016/j.actbio.2017.06.024 - , , , , :
Viscoelastic parameter identification of human brain tissue
In: Journal of the Mechanical Behavior of Biomedical Materials 74 (2017), p. 463-476
ISSN: 1751-6161
DOI: 10.1016/j.jmbbm.2017.07.014 - , , , , :
A family of hyperelastic models for human brain tissue
In: Journal of the Mechanics and Physics of Solids 106 (2017), p. 60-79
ISSN: 0022-5096
DOI: 10.1016/j.jmps.2017.05.015 - , , , , :
The mechanical importance of myelination in the central nervous system
In: Journal of the Mechanical Behavior of Biomedical Materials (2017)
ISSN: 1751-6161
DOI: 10.1016/j.jmbbm.2017.04.017
2016
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Brain stiffness increases with myelin content
In: Acta Biomaterialia (2016), p. 265–272
ISSN: 1742-7061
DOI: 10.1016/j.actbio.2016.07.040
2015
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Period-doubling and period-tripling in growing bilayered systems
In: Philosophical Magazine - (2015), p. 1-17
ISSN: 1478-6443
DOI: 10.1080/14786435.2015.1014443 - , , , , , , :
Mechanical properties of gray and white matter brain tissue by indentation
In: Journal of the Mechanical Behavior of Biomedical Materials (2015), p. 318-330
ISSN: 1751-6161
DOI: 10.1016/j.jmbbm.2015.02.024 - , , , :
Size and curvature regulate pattern selection in the mammalian brain
In: Extreme Mechanics Letters 4 (2015), p. 193-198
ISSN: 2352-4316
DOI: 10.1016/j.eml.2015.07.004 - , , :
Physical biology of human brain development
In: Frontiers in Cellular Neuroscience 9 (2015), p. 1-13
ISSN: 1662-5102
DOI: 10.3389/fncel.2015.00257 - , , :
Secondary instabilities modulate cortical complexity in the mammalian brain
In: Philosophical Magazine 95 (2015), p. 3244–3256
ISSN: 1478-6435
DOI: 10.1080/14786435.2015.1024184 - , , , :
Primary and secondary instabilities in soft bilayered systems
GAMM Jahrestagung (Lecce)
In: PAMM, Weinheim: 2015
DOI: 10.1002/pamm.201510131 - , , :
Chapter two-neuromechanics: From neurons to brain
In: Advances in Applied Mechanics 48 (2015), p. 79--139
ISSN: 0065-2156
DOI: 10.1016/bs.aams.2015.10.002
2014
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A mechanical model predicts morphological abnormalities in the developing human brain
In: Scientific Reports 4 (2014)
ISSN: 2045-2322
DOI: 10.1038/srep05644 - , , :
A mechanical approach to explain cortical folding phenomena in healthy and diseased brains
GAMM 2014 (Erlangen, Germany, 10. March 2014 - 14. March 2014)
In: PAMM, Erlangen, Germany: 2014
DOI: 10.1002/pamm.201410038 - , , :
The role of mechanics during brain development
In: Journal of the Mechanics and Physics of Solids 72 (2014), p. 75-92
ISSN: 0022-5096
DOI: 10.1016/j.jmps.2014.07.010 - , , :
A novel strategy to identify the critical conditions for growth-induced instabilities
In: Journal of the Mechanical Behavior of Biomedical Materials 29 (2014), p. 20-32
ISSN: 1751-6161
DOI: 10.1016/j.jmbbm.2013.08.017 - , , , :
Modeling and simulation of viscous electro-active polymers
In: European Journal of Mechanics A-Solids 48 (2014), p. 112-128
ISSN: 0997-7538
DOI: 10.1016/j.euromechsol.2014.02.001
2013
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On the mechanics of continua with boundary energies and growing surfaces
In: Journal of the Mechanics and Physics of Solids 61 (2013), p. 1446-1463
ISSN: 0022-5096
DOI: 10.1016/j.jmps.2013.01.007
2010
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Natural element analysis of the Cahn-Hilliard phase-field model
In: Computational Mechanics 46 (2010), p. 471-493
ISSN: 0178-7675
DOI: 10.1007/s00466-010-0490-4
2009
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Towards the treatment of boundary conditions for global crack path tracking in three-dimensional brittle fracture
In: Computational Mechanics 45 (2009), p. 91-107
ISSN: 0178-7675
DOI: 10.1007/s00466-009-0417-0
2007
- , , :
Towards the Algorithmic Treatment of 3D Strong Discontinuities
In: Communications in Numerical Methods in Engineering 23 (2007), p. 97-108
ISSN: 1069-8299
DOI: 10.1002/cnm.885 - , , , :
Modelling and Computation of 3D Discontinuities in Solids
Berlin, (Germany)
In: Proceedings GAMM'06 2007
DOI: 10.1002/pamm.200610172
2006
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On the Application of Hansbo's Method for Interface Problems
IUTAM Symposium on Discretization Methods for Evolving Discontinuities (Lyon, France)
In: Proceedings of IUTAM Symposium on Discretization Methods for Evolving Discontinuities 2006
2005
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A Finite Element Method for the Computational Modelling of Cohesive Cracks
In: International Journal for Numerical Methods in Engineering 63 (2005), p. 276-289
ISSN: 0029-5981
DOI: 10.1002/nme.1286 - , , :
A finite element method for cohesive crack modelling
Luxembourg, (28.03-)
In: Proceedings GAMM'05 2005
DOI: 10.1002/pamm.200410156
2004
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A Hybrid Discontinuous Galerkin Interface Method for the Computational Modelling of Failure
In: Communications in Numerical Methods in Engineering 20 (2004), p. 511-519
ISSN: 1069-8299
DOI: 10.1002/cnm.689 - , , :
A new approach for the FE modelling of cohesive cracks
ICTAM XXI (Warszawa, Poland)
In: Proceedings of 21st International Congress of Theoretical and Applied Mechanics 2004
2003
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Modelling of failure with a hybrid dG/ interface approach
Padua, (Italien)
In: Proceedings GAMM'03 2003 - , , :
Computational Modelling of Failure with the Discontinuous Galerkin Method
LUXFEM I (Luxembourg, Luxembourg)
In: Proceedings of the 1st International LUXFEM Conference 2003
DOI: 10.1002/pamm.200310425
